Romantic Pharmacology

1800–1850

Opium, nitrous oxide, and the observing self.

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Sources in this era

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Historical overview

On April 9, 1799, Humphry Davy inhaled nitrous oxide at the Pneumatic Institution in Bristol and recorded the experience in prose that the next half-century would treat as a model. Researches, Chemical and Philosophical (1800) opens the modern Anglophone literature of self-experiment with altered states. Within a generation Coleridge would publish 'Kubla Khan,' De Quincey the Confessions of an English Opium-Eater (1821), and Théophile Gautier his sketches of the Club des Hashischins.

The era's signature genre is the introspective first-person account: the experimenter is the experiment, and the experimental apparatus is the prose itself. In Paris, Jacques-Joseph Moreau de Tours, working at the Bicêtre, produced Du Hachisch et de l'Aliénation Mentale (1845) — the first sustained clinical psychiatric treatise on a hallucinogen, and arguably the first articulation of what Heffter, James, and Klüver would later develop into a full research program.

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Key figures in this era

HDHumphry DavySTSamuel Taylor ColeridgeTDThomas De QuinceyJMJacques-Joseph MoreauFSFriedrich SertürnerTGThéophile Gautier

Further reading

Secondary sources
  • Vetted secondary sources for this era are being prepared.