French physician P. Reinburg's account of his ayahuasca ingestion among the Záparo in May 1913, published in the Journal de la Société des Américanistes. Rather than visions, he experienced a severe toxic reaction with pulse loss, vomiting, and spasms, recorded in clinical detail.
Anthropologist Rafael Karsten's account of a Jívaro victory feast describes the natéma ceremony, in which the vision-inducing drink made from Banisteria caapi and tobacco is prepared ritually and drunk communally. The passage covers preparation, the emetic effect, and beliefs that the visions foretell prosperity.
A 1923 doctoral thesis reporting Fischer Cárdenas's isolation of the yagé alkaloid that Rafael Zerda Bayón had named telepathine (telepatina) decades earlier without isolating it. Seven case reports detail effects on human subjects, including the author's self-experiment, describing vivid dreams, visual hallucinations, and euphoria at low doses, followed by a systematic summary of physiological action.
The Montana Supreme Court reverses a Crow man's peyote conviction, finding the state failed to establish jurisdiction over an offense on the Crow Reservation. The court addresses federal Indian law and rejects the defendant's religious-use defense, but does not decide the jurisdictional question, remanding for new trial.
Rouhier's two-part dossier for Bulletin des Sciences Pharmacologiques: a translation of Barriga Villalba's 1923 paper on alkaloid yagéine, followed by Rouhier's ethnographic and pharmacological notes. Rouhier catalogues dose-dependent effects and includes chemical analysis of a Jívaro preparation.
Berlin pharmacologist Louis Lewin announces his isolation of banisterine from Banisteria caapi and its identity to harmine. He describes animal experiments and preliminary human trials showing that banisterine relieved the muscular rigidity of encephalitis lethargica (post-influenza sleeping sickness).
A Berkeley anthropologist's field survey of Mazatec witchcraft from a 1938 expedition to Huautla de Jiménez, Oaxaca. Hosted here is a fair-use excerpt: Johnson's eyewitness account of a curing ceremony he and his party attended on July 16, 1938 -- the first outsider-witnessed session involving the sacred mushrooms -- along with his description of the mushroom species and their ritual use among Mazatec brujos.
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The Narcotic Mushroom of the Aztecs
Schultes's botanical account of his 1938-39 fieldwork with Blas Pablo Reko among the Mazatec, tracing the teonanácatl rediscovery from Reko's 1923 letter through Robert Weitlaner's 1936 visit to Huautla de Jiménez. Schultes identifies the mushroom as Paneolus campanulatus var. sphinctrinus.
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The Narcotic Ololiuqui of the Aztecs
Schultes's botanical monograph settling the identity of ololiuqui, the Aztec morning-glory narcotic. He credits Urbina's 1897 identification as Rivea corymbosa, corrects Safford's 1915 misidentification as jimsonweed, and surveys continued ritual and medicinal use among the Chinantec, Mazatec, Mixtec, and Zapotec of Oaxaca.
Werner Stoll's first systematic clinical study of LSD, examining sixteen healthy volunteers and six schizophrenic patients, plus Stoll's own self-experiment. Published in 1947 following Hofmann's 1943 discovery at Sandoz, it established key vocabulary for psychiatric LSD research.
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A New Approach
Osmond and Smythies argue that schizophrenia involves a naturally occurring adrenaline derivative chemically close to mescaline. Hosted here is a fair-use excerpt: their case that mescaline intoxication reproduces the symptoms of acute schizophrenia, the biochemical note on how a disorder of adrenaline's transmethylation could form such a compound, and their resulting hypothesis and discussion.
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Rinkel and colleagues at Boston Psychopathic Hospital administered microgram doses of LSD tartrate to normal volunteers and schizophrenic, depressive, and paranoid patients. They reported the drug reliably produced thought disorder, hallucination, and depersonalization resembling clinical schizophrenia.
A memo from anthropologist [Margaret Mead](/biographies/margaret-mead)'s papers at the Library of Congress, recording her interest in LSD and other psychedelics in the summer of 1954 and her work with [Harold Abramson](/biographies/harold-abramson)'s research team, including [Conan Kornetsky](/biographies/conan-kornetsky) and [Murray Jarvik](/biographies/murray-jarvik).
I. Effects in Former Morphine Addicts and Development of Tolerance During Chronic Intoxication
Harris Isbell and colleagues at the NIMH Addiction Research Center in Lexington, Kentucky, gave LSD daily for up to eighty-five days to former morphine addicts to measure tolerance and compare effects to psychosis. They found rapid tolerance to both physiological and mental effects, which disappeared upon discontinuation.
Osmond surveyed psychotomimetic agents and proposed new terminologies, settling on "psychedelic, mind-manifesting" as his choice. This paper put the word into circulation among psychiatrists, coining the term still used today.
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R. Gordon Wasson's photo-essay in Life magazine announcing that he and photographer Allan Richardson had participated in a Mazatec mushroom ceremony near Huautla de Jiménez in June 1955. The article, illustrated with color photographs and watercolor plates, named Roger Heim as Wasson's collaborator.
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Foundations for a Combined Therapeutic Technique
Luisa G. de Álvarez de Toledo's paper to the Argentine Psychoanalytic Association in Buenos Aires on September 10, 1957, setting out a method for combining LSD sessions with psychoanalysis. Case reports by Alberto E. Fontana and Francisco Pérez Morales follow. It is one of the earliest attempts in Latin America to fit LSD into psychoanalytic treatment.
The Tenth Circuit affirms dismissal of a Native American Church suit against the Navajo Tribal Council's 1940 peyote ban, holding that the First Amendment does not apply to tribal governments unless Congress extends it. The court treats tribes as sovereign nations outside the federal Constitution.
Side Effects and Complications
Sidney Cohen surveyed researchers at the VA Neuropsychiatric Hospital who had administered LSD or mescaline to nearly 5,000 subjects across more than 25,000 doses. He found no cases of serious prolonged physical harm and quantified low rates of suicide attempts, psychotic breaks over 48 hours, and other adverse effects.
A declassified Army Chemical Research and Development Laboratories report on EA 1729 (LSD-25) as a non-lethal incapacitating agent. Includes clinical studies from 1955-1960 and September 1958 field tests at Fort Bragg in which whole military units were dosed with LSD and evaluated on operational tasks; all units proved unable to perform their missions.
A newspaper report that NASA had given John C. Lilly's Communication Research Institute an $80,700 contract to study communication between humans and dolphins. It shows the space-age funding behind the dolphin research that later included Lilly's LSD experiments.
The first scientific identification of Salvia divinorum, published in Harvard's Botanical Museum Leaflets. Wasson reports ingesting the Mazatec 'leaves of the Shepherdess' at two ceremonies in Oaxaca in 1961-62, attended on the second occasion by Albert Hofmann and his wife.
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The Harvard Crimson's July 1963 year-in-review covers Richard Alpert's May dismissal for giving psilocybin to an undergraduate and Timothy Leary's suspension. The article traces the dispute from March 1962 through the November 1962 warning by Dean Monro and Dr. Farnsworth.
The CIA Inspector General's internal audit of MKULTRA, documenting covert LSD and drug testing on unwitting American citizens through a Bureau of Narcotics safehouse arrangement. The Inspector General finds safeguards inadequate and recommends terminating unwitting testing on Americans.
The founding issue of The Psychedelic Review, published in June 1963 by Timothy Leary and Ralph Metzner's International Federation for Internal Freedom. Hosted here are the issue's unsigned Editorial and Statement of Purpose, which set out the journal's program and explain its choice of the word 'psychedelic.' The issue's bylined articles, by Gerald Heard, R. Gordon Wasson, and Alan Watts, are described in the front matter but not reproduced.
Drugs Open New Life: In a Drug-Filled Chalice, Total Love
George Draper's front-page story about Maureen Thompson, a Menlo Park mother of four who took LSD and mescaline in August 1961 at Myron Stolaroff's International Foundation for Advanced Study, which charged $500. She describes the session as a turning point in her life, and her husband Bill took the same treatment a week later.
A Manual Based on the Tibetan Book of the Dead
Leary, Metzner and Alpert recast the Tibetan Book of the Dead as a manual for LSD, psilocybin and mescaline sessions. Hosted here is a fair-use excerpt: the book's opening definition of 'set and setting,' and the full 'Preparation' and 'The Setting' sections, which give that idea its practical, session-by-session form.
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The California Supreme Court reverses the peyote convictions of four Navajo men arrested at a Native American Church meeting near Needles in 1962. Justice Tobriner's opinion describes the all-night ceremony, its officers and its ritual objects before reaching the First Amendment question.
The poet Allen Ginsberg (1926–1997) testified on June 14, 1966, before the special Senate Judiciary subcommittee holding hearings on narcotic rehabilitation and LSD on college campuses, with Quentin N. Burdick (1908–1992) presiding. He read a long prepared statement describing his visionary experience of 1948 and his use of peyote, mescaline, LSD, and ayahuasca, then argued from newspaper coverage and the medical literature that LSD's dangers had been exaggerated and that research should be expanded. The record hosts the full printed text, pp. 487–509, including his questioning by Burdick and Jacob K. Javits (1904–1986), his list of proposed research topics (Exhibit No. 76), and the references he put into the record.
Timothy Leary (1920–1996), then president of the Castalia Foundation at Millbrook, New York, testified on May 13, 1966, before the special Senate Judiciary subcommittee chaired by Thomas J. Dodd (1907–1971) that was holding hearings on narcotic addict rehabilitation and on LSD use on college campuses. Leary proposed licensing adults to use psychedelics and offering supervised university courses, and he sparred at length with Senator Edward M. Kennedy (1932–2009) over control, possession, and danger. The record hosts the full printed exchange, pp. 238–258, from Dodd's introduction to the recess.
A Chilean psychiatrist's report on harmala alkaloids, ayahuasca-related beta-carbolines, and comparative human experiments with harmaline and mescaline at the University of Chile.
A conversation among Leary, Ginsberg, Snyder, and Watts, taped aboard Watts's houseboat and published in San Francisco Oracle no. 7 (February 1967). Hosted here is the opening run of the conversation, in which the four debate dropping out of mainstream society versus working within it, and trace the psychedelic movement's lineage back through earlier utopian and religious dissent. The full conversation continues on to LSD, utopian withdrawal, and post-drop-out economics.
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Judge Gesell denies the Neo-American Church's motion to dismiss LSD and marihuana charges against a minister. The court catalogs the church's symbols and regalia, concludes it lacks genuine religious doctrine, and rejects an equal-protection claim based on the Native American Church's peyote exemption.
Banisteriopsis caapi
A Colombian Amazon ethnographic study placing Tukano use of Banisteriopsis caapi, or yajé, within a wider cultural system of mythology, ritual, symbolism, perception, and social knowledge.
Proceedings of a Conference Held at the National Institute of Mental Health
Proceedings of an NIMH conference held September 29, 1967, on adverse reactions to hallucinogenic drugs, published 1969. Addressed LSD's alleged chromosomal and teratogenic effects and the government's challenge in communicating risks to the drug-using public without propaganda.
Timothy Leary's testimony for the defense at the Chicago conspiracy trial in December 1969, questioned by William Kunstler and cross-examined by prosecutor Thomas Foran. Leary describes his career and his 1968 meetings with Abbie Hoffman and Jerry Rubin about the planned convention protests, and says the young people coming to Chicago feared violence from the police and National Guard.
Lisa Bieberman's December 1970 bulletin explains the Comprehensive Drug Abuse Prevention and Control Act, signed on October 27, 1970, which placed LSD and other psychedelics in Schedule I. She criticizes its penalties, its "continuing criminal enterprise" and "dangerous special drug offender" provisions, and its no-knock searches, then argues against the claim that drug-induced religious experience is "unnatural."
Lisa Bieberman's October 1970 bulletin reviews the two studies then available on whether heavy LSD use damages the brain: Sidney Cohen and Allen Edwards's 1968 neuropsychological tests of thirty users, and William McGlothlin's 1969 attempt to replicate them. Because their results disagree, she concludes there is no evidence of general brain damage. The issue also prints a social worker's letter about how taking LSD changed his work with drug-using teenagers.
Art Kleps's chapter on running an LSD session from The Boo Hoo Bible (1971), the Neo-American Church catechism and handbook. Hosted here is roughly the first half of the chapter: Kleps's advice on the session room, his distinction between 'Ivory' (spiritual) and 'Horny' (psychological) sessions, his view of what a guide needs to know, and his 'Good Answer / Bad Answer' examples for questions a subject might ask during a session.
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Lisa Bieberman's February 1971 bulletin responds to news that the Black Panthers in Algeria had put the escaped Timothy Leary under house arrest. It prints a memo from Humphry Osmond recalling how he and Aldous Huxley met Leary in 1960 and later came to distrust his missionary zeal, followed by Bieberman's own memories of Leary at Harvard and a critique of press claims that LSD had ruined his mind.
The Chemistry and Pharmacology of Piper methysticum and Related Species
Alexander Shulgin's review of kava, Piper methysticum, covering Pacific preparation practices, pharmacological classification, and the chemistry of kavalactones and related Piper species.
An FBI FD-302 interview (July 1974) in which recaptured Timothy Leary decodes the coded correspondence from his September 1970 prison escape. Leary identifies the Brotherhood of Eternal Love as the Laguna Beach LSD collective 'Group', Michael Randall as 'M', attorney Michael Kennedy, fellow inmate William Bellinger, and the Weathermen as 'Consultants' who staged the escape.
A short Brazilian natural-products chemistry article confirming the double use of Virola theiodora bark in Yomanê hallucinogenic snuff and arrow poison from the Tototobi River region of Roraima.
An Inspector General memorandum and attached summary paper on CIA behavioral-drug programs from BLUEBIRD (1949) through OFTEN/CHICKWIT (1967-1973). It includes the Agency's account of Frank Olson's death after being surreptitiously dosed with LSD at Deep Creek Lake in November 1953.
Rockefeller Commission findings on CIA drug testing and domestic activities
The Rockefeller Commission's 1975 report was the first major presidential inquiry to put CIA drug experiments, including LSD-related episodes and the death of Frank Olson, into an official public account. It became a bridge between the commission investigation, the Church Committee, and the later Senate MKULTRA hearing.
Staff testimony by CIA chemist Sidney Gottlieb before the Church Committee on MKULTRA. Gottlieb discusses LSD training for intelligence officers and contract research, and confirms TSS had no informed-consent policy for contracted experiments.
Full Senate report including the chapter on chemical and biological agents
Book I of the Church Committee final report, Foreign and Military Intelligence, includes the committee's findings on CIA testing and use of chemical and biological agents. The full volume places MKULTRA and LSD-related experimentation within broader findings on covert action, intelligence oversight, and congressional accountability.
An Army Inspector General review of volunteer drug testing at Edgewood Arsenal and in Intelligence Corps LSD trials (1958-1960). It finds that volunteers in the Intelligence Corps LSD program did not receive informed consent before their first dose.
1977 Senate joint hearing on LSD, behavioral research, and CIA records
A joint Senate hearing on Project MKULTRA after CIA director Stansfield Turner informed Congress that financial records had surfaced for previously destroyed behavioral-research files. The hearing and appendices document LSD-related projects, agency recordkeeping, and congressional oversight of CIA human-subjects research.
The Drug Enforcement Administration's order placing MDMA in Schedule I on an emergency basis from July 1, 1985, using powers Congress had given it the year before for so-called designer drugs. The notice cites rising recreational use, promotional parties, and a new rat study showing that the related drug MDA destroyed serotonin nerve terminals. It was issued while Judge Francis L. Young's hearings on permanent scheduling were still under way. Full text of the notice.